Surgical interventions for cervical spondylosis due to ossification of posterior longitudinal ligament

BACKGROUND Aim of this study was to evaluate the effectiveness of various surgical interventions for the management of cervical spondylosis due to the ossification of posterior longitudinal ligament (OPLL). METHODS After a comprehensive literature search in electronic databases, studies were selected by following pre-determined eligibility criteria. Random effects meta-analyses were performed to estimate the effect sizes of various surgical approaches in improving Japanese Orthopedic Association (JOA) scores at latest follow-up and meta-regression analyses were carried out to examine the factors affecting the change in JOA score. RESULTS Twenty-three studies [1576 patients; 57.83 (95% confidence interval, 95% CI: 55.98-59.68] years of age; and 73 (70-76) % males; follow-up 55.4 ± 25.7 (range 12-170) months] were included in the meta-analysis. All surgical interventions significantly (P < .00001) improved JOA score. Anterior surgical approaches had an effect size of 4.80 [4.10-5.50] and posterior approaches with laminectomy and laminoplasty improved JOA score by 3.57 [2.39-4.75] and 3.99 [3.65-4.32], respectively. Improvement in JOA score was significantly inversely related to the preoperative JOA score (P < .00001). Surgical interventions did not significantly affect cervical lordosis at the latest follow-up. CONCLUSION Surgical interventions for cervical spondylosis due to OPLL significantly improve JOA score as observed at the latest follow-up and this is found to be significantly inversely associated with preoperative JOA score.